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word count: 221 / 250 max. Introduction word count: 644 / 750 max. Discussion word count: 1500 / 1500 max. Abbreviations P450, cytochrome P450; HLM, human liver microsomes; HPLC, high-performance liquid chromatography; IC50, inhibitor concentration producing 50% inhibition; kobs, inactivation rate constant, KI, inactivation binding constant; kinact, maximum inactivation rate constant; LC-MS, liquid chromatography-mass spectrometry; NCE, new chemical entity; TDI, time dependent inhibition; WDI, World Drug Index. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on March 7, 2011 as DOI: 10.1124/dmd.110.037911 at A PE T Jornals on M ay 8, 2017 dm d.aspurnals.org D ow nladed from